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PubMed · 11817574

Involvement of adenine nucleotide carrier in the mechanism of the apolipoprotein C induced decrease of membrane potential in rat liver mitochondria.

L E Panin·N I Shalbueva·A R Kolpakov·L M Polyakov
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Abstract

Apolipoprotein C (apo C) was shown to decrease the Ca2+ capacity and membrane potential of mitochondria isolated from rat liver. The specific ligands of adenine nucleotide carrier, ADP and carboxyatractyloside (CAT), inhibited the effect of apo C on the mitochondrial membrane potential. The effect of ADP and CAT was revealed in the absence of Ca2+. We conclude that in the presence of apo C, adenine nucleosides carrier transforms into a pore, and this causes the decrease in the membrane potential of the mitochondria. ADP and CAT support the primary conformation of the carrier and therefore inhibit the effect of apolipoprotein C.

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Adenosine DiphosphateAnimalsApolipoproteins CAtractylosideCalciumIn Vitro TechniquesIntracellular MembranesMaleMembrane PotentialsMitochondria, LiverMitochondrial ADP, ATP TranslocasesRatsRats, WistarJournal Article

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L E Panin, N I Shalbueva, A R Kolpakov, L M Polyakov. 2001. Involvement of adenine nucleotide carrier in the mechanism of the apolipoprotein C induced decrease of membrane potential in rat liver mitochondria.. https://pubmed.ncbi.nlm.nih.gov/11817574/

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