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The lambda switch: cI closes the gap in autoregulation.

Ann Hochschild
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Abstract

The bacteriophage lambda genetic switch is still yielding surprises. A recent study reveals that a long-range interaction involving proteins bound 2.4 kilobases away from one another on the phage genome mediates negative autoregulation, solving a long-standing puzzle concerning the regulation of lysogeny.

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Bacteriophage lambdaDimerizationGene Expression Regulation, ViralGenes, ViralHomeostasisLysogenyModels, MolecularProtein ConformationProtein SubunitsViral ProteinsJournal Article

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Ann Hochschild. 2002-02-05. The lambda switch: cI closes the gap in autoregulation.. https://doi.org/10.1016/s0960-9822(02)00667-x

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