Morphologic phenotyping with MR microscopy: the visible mouse.

G Allan Johnson; Gary P Cofer; Sally L Gewalt; Laurence W Hedlund

doi:10.1148/radiol.2223010531

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PubMed · 11867802

Morphologic phenotyping with MR microscopy: the visible mouse.

G Allan Johnson·Gary P Cofer·Sally L Gewalt·Laurence W Hedlund

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Abstract

A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype.

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Animals Contrast Media Gadolinium DTPA Imaging, Three-Dimensional Magnetic Resonance Imaging Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy Phenotype Urate Oxidase Journal Article Research Support, U.S. Gov't, P.H.S.

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G Allan Johnson, Gary P Cofer, Sally L Gewalt, Laurence W Hedlund. 2002. Morphologic phenotyping with MR microscopy: the visible mouse.. https://doi.org/10.1148/radiol.2223010531

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