Does BDNF have pre- or postsynaptic targets?

Toshiya Manabe

doi:10.1126/science.1070163

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Does BDNF have pre- or postsynaptic targets?

Toshiya Manabe

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Abstract

A type of synaptic plasticity in the brain called long-term potentiation (LTP) is thought to form the molecular basis of learning and memory. In a Perspective, Manabe discusses new findings (Kovalchuk et al.) showing brain-derived neurotropic factor modulates LTP by binding to TrkB receptors on the postsynaptic neuron.

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Animals Brain-Derived Neurotrophic Factor Calcium Calcium Channels Calcium Signaling Dentate Gyrus Electrophysiology Glutamic Acid In Vitro Techniques Long-Term Potentiation Mice Neurons Receptor, trkB Sodium Channels Synapses Synaptic Transmission Comment Journal Article

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Toshiya Manabe. 2002-03-01. Does BDNF have pre- or postsynaptic targets?. https://doi.org/10.1126/science.1070163

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