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Cardiovascular aging is associated with vitamin E increase.

Bernd van der Loo·Ralf Labugger·Claude P Aebischer·Jeremy N Skepper·Markus Bachschmid·Volker Spitzer·Juliane Kilo·Lukas Altwegg·Volker Ullrich·Thomas F Lüscher
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Abstract

BACKGROUND: Aging is an independent risk factor for the development of cardiovascular disease. Therefore, therapies to delay vascular aging may have enormous medical consequences. In this context, vitamin E is of particular interest, mainly because of its antioxidative properties. METHODS AND RESULTS: In 3-year-old rats, which are not susceptible to atherosclerosis, vitamin E levels, as measured by reversed-phase high-performance liquid chromatography, were markedly increased both in plasma and in major organs (P<0.01 to P<0.0001). The highest increase (at least 70-fold) was found in the aortic wall. CONCLUSIONS: This unexpected accumulation of vitamin E appears to be a compensatory mechanism that attempts to counterbalance age-associated oxidative stress and that may represent a self-regulatory protective adaptation.

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Adaptation, PhysiologicalAge FactorsAgingAnimalsAntioxidantsAortaCardiovascular SystemCrosses, GeneticLiverMaleModels, AnimalMyocardiumOxidative StressRatsRats, Inbred BNRats, Inbred F344SuperoxidesVitamin Egamma-TocopherolJournal ArticleResearch Support, Non-U.S. Gov't

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Bernd van der Loo, Ralf Labugger, Claude P Aebischer, Jeremy N Skepper, Markus Bachschmid, Volker Spitzer, Juliane Kilo, Lukas Altwegg, Volker Ullrich, Thomas F Lüscher. 2002-04-09. Cardiovascular aging is associated with vitamin E increase.. https://doi.org/10.1161/01.cir.0000014986.29834.71

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