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Recent developments in diisocyanate asthma.

A V Wisnewski·C A Redlich
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Abstract

Despite recent advances in our understanding of diisocyanate-induced asthma, this disease remains a perplexing phenomenon. Studies reported in the past year have focused on: (i) diisocyanate antigens; (ii) the role of airway and skin epithelium; (iii) human immune responses to exposure; (iv) neurogenic pathways; and (v) genetic factors that may confer susceptibility. These studies support the hypothesis that diisocyanate asthma results from the host immune response to these chemicals, and may represent a mixed T helper type 1/2 response. A better understanding of the pathogenesis of diisocyanate asthma should facilitate the development of better diagnostic tests and strategies for disease surveillance and intervention.

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AsthmaCyanatesGenes, MHC Class IIGenetic Predisposition to DiseaseHumansImmunoglobulin EImmunoglobulin GIsocyanatesSkinT-Lymphocytes, Helper-InducerToluene 2,4-DiisocyanateBenzhydryl CompoundsJournal ArticleReview

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A V Wisnewski, C A Redlich. 2001. Recent developments in diisocyanate asthma.. https://doi.org/10.1097/01.all.0000011003.36723.d8

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