The quantitative relations between diffusion-controlled reaction rate and characteristic parameters in enzyme-substrate reactions systems. II. Charged substrates.

C Kuo-chen; K Chih-kun

PubMed · 1198092

The quantitative relations between diffusion-controlled reaction rate and characteristic parameters in enzyme-substrate reactions systems. II. Charged substrates.

Abstract

The quantitative relationship between the spatial factor and the force-range factor on the one hand and the ionic strength and the charges of reactants on the other has been calculated for non-spherically symmetric reaction systems. New upper limits of combination reactions between enzymes and charged substrates have been obtained. Applying the calculated results to the reactions catalyzed by fumarase and D-glyceraldehyde-3 phosphate dehydrogenase, we have been able to interpret experimental phenomena which could not be accounted for by the conventional theory of the diffusion-controlled reaction. Furthermore, the conditions under which the Bronsted equation is valid in the non-equilibrium steady state reaction system have been discussed.

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Binding Sites Diffusion Enzymes Fumarates Glyceraldehyde-3-Phosphate Dehydrogenases Kinetics Models, Chemical Osmolar Concentration Journal Article

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C Kuo-chen, K Chih-kun. The quantitative relations between diffusion-controlled reaction rate and characteristic parameters in enzyme-substrate reactions systems. II. Charged substrates.. https://pubmed.ncbi.nlm.nih.gov/1198092/

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