PubMed · 12023113
Single-bead analysis in combinatorial chemistry.
Abstract
Notable limitations have previously prevented the wide application of split synthesis. However, recent developments in highly condensed and miniaturized biological screening and single-bead analysis methods have argued for a revival of split combinatorial synthesis. Although there are still many challenges, we are now in a much better position to accomplish high-throughput analysis and screening of one-bead-one-compound libraries.
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Bing Yan. 2002. Single-bead analysis in combinatorial chemistry.. https://doi.org/10.1016/s1367-5931(02)00325-3
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