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Multicomponent lifetime-based pH sensors utilizing constant-lifetime probes.

William D Bare·Nathan H Mack·Wenying Xu·J N Demas·B A Degraff
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Abstract

A multicomponent luminescent sensor system is described that uses probe species with constant lifetimes to generate an analyte-dependent change in the apparent sensor lifetime. This new sensing scheme not only allows for lifetime-based measurement techniques to be applied to sensors that employ static quenching interactions but also provides the ability to vary the sensitivity of the sensor system with simple changes in instrumental parameters. A model for the multicomponent sensor is presented, followed by data measured using a prototype pH sensor based on the model.

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Biosensing TechniquesHalf-LifeHydrogen-Ion ConcentrationLuminescent MeasurementsSensitivity and SpecificityJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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William D Bare, Nathan H Mack, Wenying Xu, J N Demas, B A Degraff. 2002-05-01. Multicomponent lifetime-based pH sensors utilizing constant-lifetime probes.. https://doi.org/10.1021/ac0110799

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