PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 12051074

[Tissue engineering].

J A Jansen
View original source ↗Export metadata ↓

Abstract

Tissue engineering is a fast developing multidisciplinary field. Both from a medical and social point of view, there is great need to safe tissues and organs to overcome the shortage of donor organs and to reduce the health care cost. At the same time, progress made in the field of molecular sciences as well as in biomaterials and chemical engineering, offers great possibilities to manipulate cells, growth factors and carrier materials in such a way that growth of tissues can be achieved.

Explore related subjects

Bone RegenerationHumansOsseointegrationRegenerationTissue DonorsTissue EngineeringTissue TransplantationEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J A Jansen. 2002. [Tissue engineering].. https://pubmed.ncbi.nlm.nih.gov/12051074/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2016

A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair.

3D bioprinting has begun to show great promise in advancing the development of functional tissue/organ replacements. However, to realize the true potential of 3D bioprinted tissues for clinical use requires the fabrication of an interconnected and effective vascular network. Solving this challenge is critical, as human tissue relies on an adequate network of blood vessels to transport oxygen, nutrients, other chemicals, biological factors and waste, in and out of the tissue. Here, we have successfully designed and printed a series of novel 3D bone scaffolds with both bone formation supporting structures and highly interconnected 3D microvascular mimicking channels, for efficient and enhanced osteogenic bone regeneration as well as vascular cell growth. Using a chemical functionalization process, we have conjugated our samples with nano hydroxyapatite (nHA), for the creation of novel micro and nano featured devices for vascularized bone growth. We evaluated our scaffolds with mechanical testing, hydrodynamic measurements and in vitro human mesenchymal stem cell (hMSC) adhesion (4 h), proliferation (1, 3 and 5 d) and osteogenic differentiation (1, 2 and 3 weeks). These tests confirmed bone-like physical properties and vascular-like flow profiles, as well as demonstrated enhanced hMSC adhesion, proliferation and osteogenic differentiation. Additional in vitro experiments with human umbilical vein endothelial cells also demonstrated improved vascular cell growth, migration and organization on micro-nano featured scaffolds.

Bone Regeneration↗
PubMed2003

Potential applications of photodynamic therapy in regenerative medicine.

Photodynamic therapy (PDT) is an emerging field that uses light-activated drugs to produce specific biological effects in cells and tissues. Its particular strengths arise from the ability to spatially localize the biological responses by the way the light is applied; the range of possible mechanisms of action at the cell, tissue, and organism levels; and the combination of novel molecular and optical technologies. This paper presents the basic principles of PDT and considers some of the possible applications in regenerative medicine.

Bone Regeneration↗