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Genes coding structural proteins in the Leishmania braziliensis complex.

C Padilla·T Barreto·M De Los Santos·D C Barker·C Carrillo·Y Montoya
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Abstract

Acidic ribosomal P1 and P2b proteins, referred to as P proteins, and histone H3 are reported for first time in the Leishmania braziliensis complex. Deoxyribonucleic acid analysis and multiple sequence alignment suggest that both P proteins may maintain their structural function in the ribosomal stalk, in spite of the high rate of mutations detected. The deduced amino acid sequence of protein P1 showed 51% identity with Trypanosoma cruzi protein P1 and protein P2b showed 61% identity with T. cruzi protein P2b. Another conserved protein, L. (Viannia) braziliensis histone H3, showed 82% and 70% identity with histone H3 of L. (Leishmania) infantum and T. cruzi, respectively. The N-terminal end of this histone is divergent in comparison with the consensus eukaryotic sequence. Their predicted tridimensional structure was designed.

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Amino Acid SequenceAnimalsBase SequenceConserved SequenceDNA, ProtozoanGenes, ProtozoanHistonesLeishmania braziliensisMolecular Sequence DataPhosphoproteinsProtein Structure, TertiaryProtozoan ProteinsRibosomal ProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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C Padilla, T Barreto, M De Los Santos, D C Barker, C Carrillo, Y Montoya. 2002. Genes coding structural proteins in the Leishmania braziliensis complex.. https://doi.org/10.1016/s0035-9203(02)90051-9

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