Toward cell specificity in SCA1.

Sandrine Humbert; Frédéric Saudou

doi:10.1016/s0896-6273(02)00715-8

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PubMed · 12062012

Toward cell specificity in SCA1.

Sandrine Humbert·Frédéric Saudou

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Abstract

Transcriptional dysregulation appears as an emerging and unifying pathogenic mechanism in polyQ neurodegenerative disorders such as Spinocerebellar ataxias and Huntington's disease. It is unclear how cell death specificity occurs in these diseases. In this issue of Neuron, link polymerase II, a general component of the transcriptional machinery, to PQBP-1, a cerebellar enriched protein, thus providing insight into the selectivity of neuronal death in SCA1.

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Ataxin-1 Ataxins Carrier Proteins Cell Death DNA-Binding Proteins Humans Huntingtin Protein Huntington Disease Nerve Tissue Proteins Nuclear Proteins Peptides Spinocerebellar Ataxias Transcription Factors Trinucleotide Repeat Expansion Journal Article Review Comment

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Sandrine Humbert, Frédéric Saudou. 2002-05-30. Toward cell specificity in SCA1.. https://doi.org/10.1016/s0896-6273(02)00715-8

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