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PubMed · 12121657

Further checkpoints in Th1 development.

Douglas S Robinson·Anne O'Garra
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Abstract

Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

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GlycoproteinsHumansInterleukin-12Interleukin-18InterleukinsMinor Histocompatibility AntigensModels, BiologicalReceptors, CytokineTh1 CellsJournal ArticleResearch Support, Non-U.S. Gov'tReviewComment

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Douglas S Robinson, Anne O'Garra. 2002. Further checkpoints in Th1 development.. https://doi.org/10.1016/s1074-7613(02)00331-x

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