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PubMed · 121254

[Gonadostatin and gonadocrinin, polypeptides of ovarian origin with hypophysiotropic activity].

S Y Ying·R Guillemin
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Abstract

Crude acetic acid extract of Rat ovaries pretreated with pregnant mare serum (PMSG) contains native peptides with two types of separable biological activities: one, molecular weight greater than 10,000 dalton inhibits the secretion of both LH and FSH as stimulated by luteinizing hormone releasing factor (LRF) in a pituitary monolayer culture system and is referred to as gonadostatin; the other, less than 3,500 dalton, stimulates the secretion of gonadotropins and is designated as gonadocrinin. The biological activities of ovarian gonadocrinin can be competitively inhibited by an LRF-analog-antagonist, D-Phe2, D-Trp6-LRF. These ovarian peptides may participate in physiological control of pituitary LH/FSH secretion.

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AnimalsCells, CulturedFemaleFollicle Stimulating HormoneGonadotropin-Releasing HormoneGonadotropins, EquineLuteinizing HormoneMaleOvaryPeptidesPituitary GlandPituitary Hormone Release Inhibiting HormonesPituitary Hormone-Releasing HormonesRatsJournal Article

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S Y Ying, R Guillemin. 1979-11-19. [Gonadostatin and gonadocrinin, polypeptides of ovarian origin with hypophysiotropic activity].. https://pubmed.ncbi.nlm.nih.gov/121254/

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