Structure and function of water channels.

Yoshinori Fujiyoshi; Kaoru Mitsuoka; Bert L de Groot; Ansgar Philippsen; Helmut Grubmüller; Peter Agre; Andreas Engel

doi:10.1016/s0959-440x(02)00355-x

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Structure and function of water channels.

Yoshinori Fujiyoshi·Kaoru Mitsuoka·Bert L de Groot·Ansgar Philippsen·Helmut Grubmüller·Peter Agre·Andreas Engel

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Abstract

All aquaporins are efficient water transporters, while sustaining strict selectivity, even against protons, thereby maintaining the proton gradient across the cell membrane. Recently solved structures of these membrane channels have helped us to understand this remarkable property.

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Aquaporins Crystallography, X-Ray Membrane Proteins Models, Biological Models, Chemical Models, Molecular Protein Conformation Structure-Activity Relationship Water Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Yoshinori Fujiyoshi, Kaoru Mitsuoka, Bert L de Groot, Ansgar Philippsen, Helmut Grubmüller, Peter Agre, Andreas Engel. 2002. Structure and function of water channels.. https://doi.org/10.1016/s0959-440x(02)00355-x

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