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Salmonella selectively stops traffic.

Ferric Fang·Andrés Vazquez-Torres
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Abstract

The intracellular pathogen Salmonella replicates in infected host cells within a specialized vacuole referred to as the Salmonella-containing vacuole (SCV). Effector molecules encoded by the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (TTSS) are essential for Salmonella to survive in the intracellular environment. It was previously shown that SPI-2 allows Salmonella to inhibit the recruitment of NADPH phagocyte oxidase-containing vesicles to SCVs. New research has now revealed that SPI-2 effectors also interfere with the colocalization of inducible nitric oxide synthase (iNOS) to SCVs, thus protecting the pathogen from the antimicrobial actions of reactive nitrogen species.

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Bacterial ProteinsMembrane ProteinsNADPH OxidasesNitric Oxide SynthaseNitric Oxide Synthase Type IIPhagocytesSalmonellaJournal ArticleComment

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Ferric Fang, Andrés Vazquez-Torres. 2002. Salmonella selectively stops traffic.. https://doi.org/10.1016/s0966-842x(02)02423-x

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