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PubMed · 12267110

Sustained release systems for ethinylestrogens.

V Diaz-sanchez·J Garza-flores·M D Rosales·S J Thomas
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Abstract

The immunoreactive serum concentration of ethinylestradiol (EE) was measured by a specific radioimmunoassay after a single intramuscular administration of a combined preparation of Norethindrone (NET) and Mestranol (ME). The mean peak serum value for the 6 women studied was 278.5 pm/m1/m2 of body surface area (BSA), and was reached 11.17 days after dosing, with a half-life of absorption (T1/2 abs) of 9.37 days. In 5 out of 6 subjects EE was detectable in the circulaton for 21 days after injection. The mean serum concentration time curve was calculated in 2720.67 pg/day/m1/m2. The shape of the 1-21 day concentration-time curve shows a sustained release pattern, suitable for a long acting fertility regulation method.

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BiologyContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptives, Oral, HormonalEconomicsEndocrine SystemEthinyl EstradiolEvaluation Studies as TopicFamily Planning ServicesHormonesPhysiologyReproductive Control AgentsResearchTechnologyClinical ResearchContraceptive Agents, EstrogenEconomic FactorsEvaluationFamily PlanningResearch And DevelopmentResearch MethodologyJournal Article

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V Diaz-sanchez, J Garza-flores, M D Rosales, S J Thomas. 1985. Sustained release systems for ethinylestrogens.. https://pubmed.ncbi.nlm.nih.gov/12267110/

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