PubMed · 12315469
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
U.S. Conference of Mayors, Fund for Human Dignity. 1988. Local AIDS task forces / coordinating bodies.. https://pubmed.ncbi.nlm.nih.gov/12315469/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
In this paper, we propose a multivariate Plackett-Dale model for survival outcomes. A pseudo-likelihood method for the estimation of the parameters is proposed and these ideas are applied to two case studies. The modelling approach is similar in spirit but different from Parner's approach. The first study is in AIDS, where the overall survival time and different opportunistic infections in HIV-infected patients are studied. The second study is on adoption data where the association of the survival times within families is modelled, illustrating the use of the proposed methodology for the context of population genetics.
Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL) genes. The coding regions and promoters of these genes were resequenced in a cohort of 212 HIV-1-seropositive patients presenting extreme disease phenotypes and 155 healthy controls of Caucasian origin. Overall, 33 single nucleotide polymorphisms (SNPs) with an allele frequency >1% were identified and evaluated for their association with disease progression. Among them, 14 polymorphisms were newly characterized. We did not find any statistically significant association of Fas and FasL polymorphisms and haplotypes with AIDS progression.