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PubMed · 12338632

Subdermal levonorgestrel implants: serum androgens.

M I Osman·M I Abdalla·M H Toppozada·M A Bayad·I I Ibrahim·E Z Hafez
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Abstract

Serum levels of androstenedione, dihydrotestosterone, and testosterone were determined by radioimmunoassay procedures in 25 female volunteers using subdermal levonorgestrel implants as a contraceptive. Mean serum androstenedione levels were increased after 1 and 6 months in comparison with preimplantation levels, the increase being significant only after 1 month. This could be attributed to increased production from the adrenal or ovaries and/or changes in clearance rate. Testosterone levels showed approximately 24% increase above basal values after 6 months' use of levonorgestrel implants, which was attributed to concomitant increases in androstenedione levels. The implication of these results is discussed.

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Age FactorsAndrogensBiologyContraceptionContraceptive AgentsContraceptive Agents, FemaleEndocrine SystemFamily Planning ServicesHormonesInjectionsLevonorgestrelParityPhysiologyReproductive Control AgentsTestosteroneAndrogens--analysisContraceptive Agents, ProgestinContraceptive Agents--administraction and dosageContraceptive MethodsFamily PlanningInjectablesLevonorgestrel--administraction and dosageJournal Article

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M I Osman, M I Abdalla, M H Toppozada, M A Bayad, I I Ibrahim, E Z Hafez. 1983. Subdermal levonorgestrel implants: serum androgens.. https://pubmed.ncbi.nlm.nih.gov/12338632/

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