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Sib-parentage testing using molecular markers when parents are unknown.

D García·C Carleos·D Parra·J Cañón
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Abstract

The formulae for computing the so-called Sib Index using codominant alleles for (1) full-sib and (2) half-sib parentage are given. Hypothesis testing is based on the distribution of conditional likelihood ratio or Bayes' factor. Thresholds for rejecting the null hypothesis and P-values were obtained in function of the number of alleles and their frequency distributions. Simulations showed that a relatively low number of marker systems (e.g. 20) are enough to accept the hypothesis of sib parentage with a reasonable power for usual significance levels, but that a higher number would be necessary if full-sib against half-sib parentage is the contrast to be carried out. The effect of sampling variation on the allele frequencies on power calculations is also analysed.

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AllelesAnimalsBreedingDogsFemaleGenetic MarkersGenotypeLikelihood FunctionsMaleModels, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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D García, C Carleos, D Parra, J Cañón. 2002. Sib-parentage testing using molecular markers when parents are unknown.. https://doi.org/10.1046/j.1365-2052.2002.00882.x

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