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Locus control regions.

Qiliang Li·Kenneth R Peterson·Xiangdong Fang·George Stamatoyannopoulos
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Abstract

Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. Although their composition and locations relative to their cognate genes are different, LCRs have been described in a broad spectrum of mammalian gene systems, suggesting that they play an important role in the control of eukaryotic gene expression. The discovery of the LCR in the beta-globin locus and the characterization of LCRs in other loci reinforces the concept that developmental and cell lineage-specific regulation of gene expression relies not on gene-proximal elements such as promoters, enhancers, and silencers exclusively, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations.

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AcetylationAnimalsCell LineageChickensChromatinDNA ReplicationEnhancer Elements, GeneticGene Expression RegulationGlobinsHeterochromatinHistonesHumansLocus Control RegionMiceRatsTranscription, GeneticVertebratesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Qiliang Li, Kenneth R Peterson, Xiangdong Fang, George Stamatoyannopoulos. 2002-11-01. Locus control regions.. https://doi.org/10.1182/blood-2002-04-1104

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