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Vitamin A and kidney development.

Thierry Gilbert
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Abstract

Recent advances in developmental nephrology have provided new evidence that retinoids, vitamin A and its active metabolites such as all-trans retinoic acid, profoundly influence renal organogenesis. Retinoids are acknowledged as potent nephron mass regulators. They regulate embryonic kidney patterning through control of Ret expression in a dose-dependent manner, which modulates ureteric bud branching morphogenesis. Analysis of retinoid availability and utilization provides additional evidence of retinoid involvement at sites of epithelial-mesenchymal interactions, suggesting a tight control of vitamin A homeostasis for proper renal morphogenesis and differentiation. This provides a rationale for the search for and identification of retinoid target genes.

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AnimalsEmbryonic and Fetal DevelopmentFetusHumansKidneyNephronsVitamin AJournal Article

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Thierry Gilbert. 2002. Vitamin A and kidney development.. https://doi.org/10.1093/ndt%2F17.suppl_9.78

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