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PubMed · 12395968

CAPS--coronary-assisted perfusion system.

Abstract

For the past 35 years the use of the extracorporeal bypass circuit has been a mainstay for coronary artery bypass grafting (CABG) in cardiac surgery arena. Since John Gibbon's early design, evolution of the pump has expanded rapidly with new techniques and engineering. The cardiopulmonary bypass (CPB) circuit has allowed cardiovascular surgeons to perform complete revascularization in a motionless and bloodless field. Presently, there is a new focus on CABGs because of new engineering designs of retractors and stabilizers, robotic techniques, and the monetary issues of cost and length of stay. Surgeons at our hospital perform 70% of CABG procedures off pump. We have developed a coronary-assisted perfusion system called CAPS. This is a simple shunt system that uses existing pump hardware to deliver arterial blood to the myocardium after the completion of the distal anastomosis. Flow is regulated by monitoring a pressure-sensing display either at systemic or suprasystemic pressure. Temperature of the blood is maintained with a Vanguard BCD heat exchanger (COBE Cardiovascular Inc., Arvada, CO) with a built-in temperature probe port. This system is capable of delivering optional agents for coronary vasodilatation, myocardial resuscitation, and performance through a connection to any standard medication infusion pump. The advantages of this system are that it is safe, requires no additional perfusion hardware, cost effective, easy to setup, has a low and rapid prime, has both inflow and outflow pressure monitoring sites, has heat a exchanger with temperature monitor, and has a drug additive port for pharmacologic infusion.

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BibTeXRIS

C Ty Walker, Timothy M Folk, Thomas A Vassiliades. 2002. CAPS--coronary-assisted perfusion system.. https://pubmed.ncbi.nlm.nih.gov/12395968/

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Cardiopulmonary Bypass↗

An alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass surgery and major abdominal surgery.

INTRODUCTION: We conducted this prospective study in order to investigate the hypotheses that an alternative pathway for fibrinolysis is activated in patients who have undergone cardiopulmonary bypass (CPB) surgery and major abdominal surgery and that the levels of fibrin degradation products digested by polymorphonuclear neutrophil elastase (elastase-XDP) and the D-dimer increase in the patients' plasma. MATERIALS AND METHODS: We studied a total of 77 patients who were scheduled to undergo either CPB surgery (36 patients) or major abdominal surgery (41 patients) and then measured the elastase-XDP and D-dimer levels at several time points both during and after the surgeries. The CPB surgery was divided into surgery for aortic dissection (AD) and cardiac surgery. The major abdominal surgery consists of hepatic resection and esophagectomy. RESULTS: The elastase-XDP and D-dimer levels significantly increased in the patients who underwent both CPB surgery and major abdominal surgery. The elastase-XDP levels in AD surgery showed highest values at the end of the CPB, while the levels in the other surgeries reached their peak on the day after the surgery. Statistical difference was seen in the levels of elastase-XDP among the three subgroups undergoing a hepatic resection. While we found significant correlations between the levels of elastase-XDP and D-dimer in patients undergoing CPB surgery and a subsegmentectomy of a cirrhotic liver, the correlation coefficients were markedly low in comparison to those of the other surgeries. CONCLUSIONS: Our findings demonstrated that the elastase-mediated pathway of fibrinolysis is activated to varying degrees depending on the surgery performed. Variations in the correlation coefficients between the levels of elastase-XDP and D-dimer may suggest that elastase-mediated fibrinolysis play a different role from the physiological fibrinolysis mediated by plasmin.

Cardiopulmonary Bypass↗