Leiomyosarcoma showing partial synthetic-phase differentiation.

Brian Eyden; S Sankar Banerjee

doi:10.1080/01913120290104629

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Leiomyosarcoma showing partial synthetic-phase differentiation.

Brian Eyden·S Sankar Banerjee

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Abstract

An unusual leiomyosarcoma in the thigh of a 53-year-old woman is described. Tumor cells were spindled and positive for muscle immuno-markers. Some cells exhibited typical smooth-muscle ultrastructure--abundant myofilaments, focal densities, attachment plaques, plasmalemmal caveolae, and lamina. Others had fewer myofilaments and prominent rough endoplasmic reticulum. These features indicated a variable phenotype that included synthetic-phase (matrigenic) differentiation. Synthetic-phase cells were distinguished from myofibroblasts by typical smooth-muscle surface features in the absence of fibronexus junctions. In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation.

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Biomarkers, Tumor Cell Transformation, Neoplastic Female Humans Immunohistochemistry Leiomyosarcoma Microscopy, Electron Middle Aged Neoplasms, Second Primary S Phase Soft Tissue Neoplasms Thigh Case Reports Journal Article

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Brian Eyden, S Sankar Banerjee. Leiomyosarcoma showing partial synthetic-phase differentiation.. https://doi.org/10.1080/01913120290104629

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