NMDA receptor pathways as drug targets.

John A Kemp; Ruth M McKernan

doi:10.1038/nn936

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PubMed · 12403981

NMDA receptor pathways as drug targets.

John A Kemp·Ruth M McKernan

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Abstract

Since the mid 1980s, there has been a great deal of enthusiasm within both academia and industry about the therapeutic potential of drugs targeting the NMDA subtype of glutamate receptors. That early promise is just beginning to translate into approvable drugs. Here we review the reasons for this slow progress and critically assess the future prospects for drugs that act on NMDA receptor pathways, including potential treatments for some major disorders such as stroke and Alzheimer's disease, for which effective therapies are still lacking.

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Animals Brain Brain Diseases Drug Design Drug Industry Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Humans Neural Pathways Neurosciences Receptors, N-Methyl-D-Aspartate Journal Article Review

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John A Kemp, Ruth M McKernan. 2002. NMDA receptor pathways as drug targets.. https://doi.org/10.1038/nn936

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