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PubMed · 12408836

Spinsters, synaptic defects, and amaurotic idiocy.

Subhabrata Sanyal·Mani Ramaswami
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Abstract

In this issue of Neuron, Sweeney and Davis present a beautiful characterization of Drosophila mutants in a gene named spinster. The results indicate a function of the endocytic pathway in regulating transforming growth factor-beta (TGF-beta) signaling at the Drosophila motor synapse. This study provides important new information at an intersection of several disciplines, including membrane traffic, lipid organization, synaptic signaling, and neurodegenerative lysosomal storage disease.

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AnimalsHumansDrosophila melanogasterDrosophila ProteinsEndocytosisLysosomal Storage Diseases, Nervous SystemMembrane ProteinsMutationNeuromuscular JunctionSignal TransductionSynaptic TransmissionTransforming Growth Factor betaJournal ArticleComment

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Subhabrata Sanyal, Mani Ramaswami. 2002-10-24. Spinsters, synaptic defects, and amaurotic idiocy.. https://doi.org/10.1016/s0896-6273(02)01015-2

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