Linking DNA damage to cell cycle checkpoints.

Temesgen Samuel; H Oliver Weber; Jens Oliver Funk

PubMed · 12429926

Linking DNA damage to cell cycle checkpoints.

Temesgen Samuel·H Oliver Weber·Jens Oliver Funk

Abstract

Cell cycle checkpoints constitute a network of signal transduction mechanisms to monitor DNA damage and replication and thereby regulate progression through the cell cycle. A series of events is triggered in cells upon DNA damage. Here we describe a framework for the understanding of the functions of the core components involved in the cell cycle response to DNA damage and the relevance to the origin of cancer.

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Cell Cycle Checkpoint Kinase 2 Cyclin-Dependent Kinase Inhibitor p21 Cyclins DNA Damage G2 Phase Humans Mitosis Models, Biological Neoplasms Protein Kinases Protein Serine-Threonine Kinases Signal Transduction Tumor Suppressor Protein p53 Ultraviolet Rays Journal Article Research Support, Non-U.S. Gov't Review

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Temesgen Samuel, H Oliver Weber, Jens Oliver Funk. Linking DNA damage to cell cycle checkpoints.. https://pubmed.ncbi.nlm.nih.gov/12429926/

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