PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 12462471

The knee: bone marrow abnormalities.

Michelle S Barr·Mark W Anderson
View original source ↗Export metadata ↓

Abstract

MRI is clearly the imaging modality of choice for detecting and exploring joint, osseous, and soft tissue injuries in the lower extremity and throughout the musculoskeletal system. Its ability to detect and differentiate the various forms of marrow pathology is unrivaled, and as such it should be obtained early in the work-up of a patient with a suspected marrow abnormality. Additionally, the radiologist must be familiar with the MRI appearances of normal marrow and the most common types of marrow pathology if its diagnostic power is to be fully realized.

Explore related subjects

ArthritisBone Marrow DiseasesHumansKnee InjuriesKnee JointMagnetic Resonance ImagingOsteonecrosisJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Michelle S Barr, Mark W Anderson. 2002. The knee: bone marrow abnormalities.. https://doi.org/10.1016/s0033-8389(02)00051-9

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2003

Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays.

The cytokine tumor necrosis factor alpha (TNF-alpha) is a critical effector of the pathogenesis of rheumatoid arthritis (RA). We used oligonucleotide microarray (OM) analysis to assess TNF-alpha-modulated gene expression in cultured primary human synoviocytes in vitro. Genes identified include cytokines and inflammatory mediators, extracellular matrix and adhesion molecules, cell cycle and proliferation related proteins, transcription related proteins, and apoptotic mediators. OM identified 1185 differentially expressed genes in TNF-alpha-treated synoviocytes. The regulation of Nef-associated factor-1 (Naf1), an A20-binding, nuclear factor kappa B (NFkappaB) inhibitory protein was probed further given its putative role as an endogenous brake for the expression of some TNF-alpha-driven genes. Naf1 mRNA levels were higher in synovial biopsies from patients with active RA and seronegative arthropathy than in those from patients with osteoarthritis. These findings underscore the value of transcriptome analysis in cytokine-activated synoviocyte cultures in vitro as a means of identifying disease-associated genes in human arthritis, and implicate Naf1 as a potential modulator of TNF-alpha bioactivity in RA.

Arthritis↗
PubMed2003

Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.

Nociceptin is a neuropeptide sharing sequence homology with classical opioid peptides but with a distinct pharmacological profile. Through activation of its receptor, NociR, nociceptin has been linked with several physiological functions in the central nervous system including memory, locomotion, and processing of pain signals. Recently, peripheral blood neutrophils (PMNs) were demonstrated to express a functional NociR, a result suggesting that additional functions of the neuropeptide remain to be elucidated. The present study investigated the possibility that PMNs may be a source of nociceptin and whether the neuropeptide elicits PMN early responses. We observed the presence of nociceptin in the synovial fluids from arthritic patients, an inflammatory milieu typically containing high numbers of PMNs. In addition, freshly isolated PMNs were found to express and secrete nociceptin following degranulation, identifying these inflammatory cells as a novel source of the neuropeptide. Incubation of PMNs with nociceptin elicited a specific pattern of cellular protein phosphorylation on tyrosine residues in a rapid and transient fashion. Moreover, nociceptin prevented intracellular accumulation of cAMP in fMLP-stimulated PMNs, an effect mimicked by the specific NociR synthetic agonist, Ro 64-6198. Taken together, these results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues.

Arthritis↗