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PubMed · 12478993

[Ovarian genes].

S Christin-Maître
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Abstract

The number of ovarian follicles decreases during genital life by apoptosis, which accelerates from 40 until the menopause. Several findings plead in favour of a genetic control of these events. Ovarian insufficiency can occur by three mechanisms: reduction in the primary follicles reserve (ataxia-telangiectasy), follicular maturation blocking (modification of the genes GDF-9 and GDF-9B, null mutation of FSH receptor gene, auto-immune polyglandular disease, PBE syndrome), or apoptosis acceleration (chemotherapy, smoking, galactosemia, Turner's syndrome). However, the aetiology of premature ovarian insufficiencies in woman remains unknown in more than 90% of the cases. Genetic studies on the family cases should make it possible to identify new genes involved in ovarian control.

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AnimalsApoptosisFemaleHumansMenopauseOvarian FollicleOvaryPrimary Ovarian InsufficiencyEnglish AbstractJournal ArticleReview

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BibTeXRIS

S Christin-Maître. 2002. [Ovarian genes].. https://doi.org/10.1016/s1297-9589(02)00449-6

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