[Prion diseases: current views].

E A Kogan; P V Zelenkov; O V Uspenskaia; Ia V Epifanov

PubMed · 12534218

[Prion diseases: current views].

E A Kogan·P V Zelenkov·O V Uspenskaia·Ia V Epifanov

Abstract

This is a review of the problem. The above diseases represent a peculiar type of fatal neurodegenerative diseases of man and animals provoker of which is prion--a low molecular anucleinic protein resistant to inactivation. Human prior diseases include fatal familial sleeplessness, Kreutzfeldt-Jakob disease, kuru, Gerstmann-Streussler-Sheinker's syndrome, etc. Prion proteins possess a characteristic capacity to change a tertiary conformation resulting in the formation of a pathological form of protein having infectious properties. Pathogenesis, morphological and clinical manifestations as well as principles of diagnosis and treatment of these diseases are discussed.

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E A Kogan, P V Zelenkov, O V Uspenskaia, Ia V Epifanov. [Prion diseases: current views].. https://pubmed.ncbi.nlm.nih.gov/12534218/

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