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An integrated computational pipeline and database to support whole-genome sequence annotation.

C J Mungall·S Misra·B P Berman·J Carlson·E Frise·N Harris·B Marshall·S Shu·J S Kaminker·S E Prochnik·C D Smith·E Smith·J L Tupy·C Wiel·G M Rubin·S E Lewis
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Abstract

We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.

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AnimalsComputational BiologyDatabases, GeneticGenomeHumansInternetSoftware DesignJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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C J Mungall, S Misra, B P Berman, J Carlson, E Frise, N Harris, B Marshall, S Shu, J S Kaminker, S E Prochnik, C D Smith, E Smith, J L Tupy, C Wiel, G M Rubin, S E Lewis. 2002-12-23. An integrated computational pipeline and database to support whole-genome sequence annotation.. https://doi.org/10.1186/gb-2002-3-12-research0081

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