Complement-inhibiting iridoids from Morinda morindoides.

Kanyanga Cimanga; Nina Hermans; Sandra Apers; Sabine Van Miert; Hilde Van den Heuvel; Magda Claeys; Luc Pieters; Arnold Vlietinck

doi:10.1021/np020215h

PubMed · 12542353

Complement-inhibiting iridoids from Morinda morindoides.

Kanyanga Cimanga·Nina Hermans·Sandra Apers·Sabine Van Miert·Hilde Van den Heuvel·Magda Claeys·Luc Pieters·Arnold Vlietinck

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Abstract

Morinda morindoides (Baker) Milne-Redhead (syn. Gaertnera morindoides Bak.) is one of the most popular medicinal plants in the Democratic Republic of Congo. In relation to its traditional use against rheumatic pains, fractionation of both the EtOAc- and the n-BuOH-soluble fraction of the 80% MeOH extract of the leaves, guided by the anticomplementary activity on the classical activation pathway, yielded eight novel iridoids (1-8), all containing a spirolactone functionality. Their structure was elucidated using spectroscopic methods. Gaertneroside 1, acetylgaertneroside 2, and gaertneric acid 5 were found to inhibit the activation of the classical pathway of the complement system, with IC(50) values between 58 and 69 microM. In addition to the biologically active flavonoids reported before from the same plant, these complement-inhibiting iridoids may contribute at least in part to the traditional use against rheumatic pains.

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Complement Inactivator Proteins Complement Pathway, Alternative Complement Pathway, Classical Democratic Republic of the Congo Dose-Response Relationship, Drug Flavonoids Hemolysis Humans Inhibitory Concentration 50 Iridoids Morinda Nuclear Magnetic Resonance, Biomolecular Plant Leaves Plants, Medicinal Journal Article Research Support, Non-U.S. Gov't

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Kanyanga Cimanga, Nina Hermans, Sandra Apers, Sabine Van Miert, Hilde Van den Heuvel, Magda Claeys, Luc Pieters, Arnold Vlietinck. 2003. Complement-inhibiting iridoids from Morinda morindoides.. https://doi.org/10.1021/np020215h

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