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An improved procedure for testing for assay linearity.

H A Ross·C G J Sweep
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Abstract

BACKGROUND: Statistical testing of assay linearity using replicate measurements made on binary mixtures of samples provides no information about the significance of any detected deviations from linearity, which may often be desirable. METHOD: Performance of additional statistical analysis of the assay data. RESULT: Objective measures for non-linearity and the minimum detectable deviation from linearity of the assay are obtained. CONCLUSION: A few additional calculations from the available data make it possible to assess whether or not an assay method needs improvement to achieve adequate performance within its intended application.

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BiochemistryChemistry, ClinicalChromatography, High Pressure LiquidElectrochemistryModels, StatisticalReproducibility of ResultsJournal Article

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H A Ross, C G J Sweep. 2003. An improved procedure for testing for assay linearity.. https://doi.org/10.1258/000456303321016204

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