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Micromonospora-produced gentamicin components.

B K Lee·R G Condon·G H Wagman·E Katz
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Abstract

After the chromatographic separation of [methyl-(14)C]gentamicin major (C) components from a large-scale radioactive fermentation (Lee et al., 1974), [methyl-(14)C]gentamicin minor (polar) components (A, B, B(1), X(2), and G-418) were isolated from subsequent chromatography of the remaining antibiotic mixture. When l-[methyl-(14)C]methionine was added at the onset of biosynthesis of the gentamicin components, incorporation of label into the minor components preceded incorporation into the major components. Degradation occurred when [methyl-(14)C]gentamicin major components (C(1), C(2) and C(1)a) were added respectively to the gentamicin-producing culture medium and shaken.

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Biodegradation, EnvironmentalCulture MediaGentamicinsMethionineMicromonosporaJournal Article

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B K Lee, R G Condon, G H Wagman, E Katz. 1976. Micromonospora-produced gentamicin components.. https://doi.org/10.1128/aac.9.1.151

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