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PubMed · 12630108

[Hydrodynamic parameters of native C-reactive protein molecule in a solution].

O P Blizniukov·L D Kozmin·V V Falikova·V N Titov·A G Belen'kiĭ·V M Tishchenko
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Abstract

The hydrodynamic properties of the C-reactive protein in solution (pH 6.8) were studied using quasi-elastic light scattering and size-exclusion liquid chromatography. It was shown that the solution containing the C-reactive protein represents a polydisperse system. The values of the translation diffusion coefficient and the apparent molecular weight of the C-reactive protein in solution at pH 6.8 were determined. The values of the translation diffusion coefficient, molecular weight and the hydration radius obtained suggest that the native pentameric C-reactive protein is the major form of the protein in solution at pH 6.8.

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C-Reactive ProteinChromatography, GelHydrogen-Ion ConcentrationImmunoelectrophoresisLightMolecular WeightPolymersScattering, RadiationSolutionsEnglish AbstractJournal Article

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O P Blizniukov, L D Kozmin, V V Falikova, V N Titov, A G Belen'kiĭ, V M Tishchenko. [Hydrodynamic parameters of native C-reactive protein molecule in a solution].. https://pubmed.ncbi.nlm.nih.gov/12630108/

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