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PubMed · 12670730

Location, location, location.

Paul A Insel
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Abstract

Increasing evidence documents the co-localization of molecules involved in both the activation and de-activation (desensitization) of signal transduction, especially in G protein-coupled receptor and heterotrimeric G protein-mediated signalling. Of particular note are the recent findings regarding recruitment of cyclic nucleotide phosphodiesterase to beta-arrestin in transfected HEK293 cells and in native cardiac myocytes. Co-localization of G protein pathway signalling molecules probably contribute to both spatial and temporal regulation of signal transduction.

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AnimalsArrestinsCells, CulturedHeterotrimeric GTP-Binding ProteinsHumansKidneyMuscle CellsMyocardiumPhosphoric Diester HydrolasesProtein KinasesReceptor Cross-TalkReceptors, G-Protein-CoupledSignal Transductionbeta-ArrestinsJournal Article

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Paul A Insel. 2003. Location, location, location.. https://doi.org/10.1016/s1043-2760(03)00029-8

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