Repaglinide at a cellular level.

M Krogsgaard Thomsen; K Bokvist; M Høy; K Buschard; J J Holst; P Lindström; J Gromada

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PubMed · 12702003

Repaglinide at a cellular level.

M Krogsgaard Thomsen·K Bokvist·M Høy·K Buschard·J J Holst·P Lindström·J Gromada

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Abstract

To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.

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Animals Carbamates Cyclohexanes Electrophysiology Exocytosis Hypoglycemic Agents Islets of Langerhans Membrane Potentials Nateglinide Phenylalanine Piperidines Postprandial Period Potassium Channels Rats Journal Article

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M Krogsgaard Thomsen, K Bokvist, M Høy, K Buschard, J J Holst, P Lindström, J Gromada. 2002. Repaglinide at a cellular level.. https://pubmed.ncbi.nlm.nih.gov/12702003/

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