Simple transformation method for predicting plasma drug profiles from dissolution rates.

D P Vaughan; R H Leach

doi:10.1002/jps.2600650432

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Simple transformation method for predicting plasma drug profiles from dissolution rates.

D P Vaughan·R H Leach

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Abstract

A transformation factor is described which related in vitro drug dissolution from a preparation to the corresponding in vivo plasma drug concentrations. This factor, derived from the dissolution profile and the corresponding in vivo plasma concentration of a single formulation, was used to predict plasma concentration profiles of similar formulations simply from dissolution data.

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Methods Models, Biological Pharmaceutical Preparations Solubility Time Factors Journal Article

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D P Vaughan, R H Leach. 1976. Simple transformation method for predicting plasma drug profiles from dissolution rates.. https://doi.org/10.1002/jps.2600650432

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