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Biomedical subjects

D P Vaughan

Publications and source records attributed to D P Vaughan.

9 recordsLinked to original sources
PubMed1979

Number of exponential terms describing the solution of an N-compartmental mammillary model: vanishing exponentials.

The solution for a linear mammillary model is always described by a summation of m + 1 negative exponential terms with constant coefficients. m + 1 less than or equal to N, where N is the number of compartments in the model. m is equal to the number of distinct values for the peripheral Ej values. Use is made of matrix notation and the theorems of Browne concerning the eigenvalues of a matrix. The consequences of vanishing exponentials are derived, and in particular the apparent volume of distribution frequently calculated from experimental data is shown not to be unique.

Animals↗
PubMed1976

General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy.

A constant plasma drug concentration can be achieved and maintained by the intravenous administration of an initial bolus loading dose in conjunction with a constant rate and an exponential intravenous drug infusion. The drug input required to achieve a constant plasma drug concentration is derived without making any assumptions about the nature of drug distribution within the body or elimination from the body.

Infusions, Parenteral↗
PubMed1976

The influence of smoking on the intersubject variation in pentazocine elimination.

The cumulative urinary excretion over 24 h of pentazocine, under conditions of acidic urinary pH, has been measured in smokers and non-smokers using both male and female subjects (seventy subjects in total). A restricted urban population was studied. An overall three-fold inter-subject variation in elimination was observed. The cumulative urinary excretion of pentazocine was normally distributed in both smokers and non-smokers. Smokers metabolize 40% more pentazocine than non-smokers. It is concluded that induction is principally responsible for the observed subject variability.

Adult↗