G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

James A Schouten; Sylvain Ladame; Stephen J Mason; Matthew A Cooper; Shankar Balasubramanian

doi:10.1021/ja029356w

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G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.

James A Schouten·Sylvain Ladame·Stephen J Mason·Matthew A Cooper·Shankar Balasubramanian

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Abstract

G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding affinity by approximately 1000-fold to give ligands with near micromolar affinity and >40-fold discrimination for quadruplex DNA over duplex.

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Carbocyanines Coloring Agents Combinatorial Chemistry Techniques DNA G-Quadruplexes Kinetics Ligands Oligopeptides Substrate Specificity Surface Plasmon Resonance Journal Article Research Support, Non-U.S. Gov't

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James A Schouten, Sylvain Ladame, Stephen J Mason, Matthew A Cooper, Shankar Balasubramanian. 2003-05-14. G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection.. https://doi.org/10.1021/ja029356w

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