Nuclear receptors orchestrate detoxification pathways.

Jayanta Roy-Chowdhury; Joseph Locker; Namita Roy-Chowdhury

doi:10.1016/s1534-5807(03)00131-x

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Nuclear receptors orchestrate detoxification pathways.

Jayanta Roy-Chowdhury·Joseph Locker·Namita Roy-Chowdhury

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Abstract

Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

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Animals Bilirubin Constitutive Androstane Receptor Glucuronosyltransferase Humans Inactivation, Metabolic Pregnane X Receptor Receptors, Cytoplasmic and Nuclear Receptors, Steroid Transcription Factors UGT1A1 Enzyme Journal Article Comment

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Jayanta Roy-Chowdhury, Joseph Locker, Namita Roy-Chowdhury. 2003. Nuclear receptors orchestrate detoxification pathways.. https://doi.org/10.1016/s1534-5807(03)00131-x

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