Osteoclast differentiation and activation.

William J Boyle; W Scott Simonet; David L Lacey

doi:10.1038/nature01658

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Osteoclast differentiation and activation.

William J Boyle·W Scott Simonet·David L Lacey

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Abstract

Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss.

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Animals Bone Resorption Carrier Proteins Cell Differentiation Glycoproteins Humans Membrane Glycoproteins Osteoclasts Osteoporosis Osteoprotegerin RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear Receptors, Tumor Necrosis Factor Signal Transduction Journal Article Review

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William J Boyle, W Scott Simonet, David L Lacey. 2003-05-15. Osteoclast differentiation and activation.. https://doi.org/10.1038/nature01658

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