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PubMed · 12785100

Stretching and visualizing titin molecules: combining structure, dynamics and mechanics.

Miklós S Z Kellermayer·László Grama
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Abstract

The details of the global and local structure and function of titin, a giant filamentous intrasarcomeric protein are largely undiscovered. Here we discuss a combination of bulk-solution and novel single-molecule techniques that may lend unique insights into titin's molecular dynamic, structural and mechanical characteristics.

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AnimalsBiomechanical PhenomenaConnectinDimerizationElasticityFluorescenceHumansMicromanipulationMicroscopy, Atomic ForceMicroscopy, ConfocalMicrospheresModels, MolecularMotionMuscle ProteinsProtein BindingProtein ConformationProtein DenaturationProtein IsoformsProtein KinasesRhodaminesTime FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Miklós S Z Kellermayer, László Grama. 2002. Stretching and visualizing titin molecules: combining structure, dynamics and mechanics.. https://doi.org/10.1023/a%3A1023414624092

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