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PubMed · 12789607

Multifunctional drugs for endothelial dysfunction in diabetes and glaucoma.

Paul L Wood
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Abstract

Endothelial dysfunction is a multifactorial term in that it encompasses a number of complex biochemical alterations in the ability of endothelial cells to perform their normal physiological function. These alterations are generally initiated by increased oxidative stress leading to pathological alterations in the cellular balance of mediators produced by endothelial cells. The key mediators include nitric oxide (NO), superoxide and endothelin. This review presents the current status of our knowledge of endothelial dysfunction in diabetes and in glaucoma and presents the case for evaluation of multifunctional drugs in these diseases.

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Anti-Inflammatory AgentsDiabetic AngiopathiesEndothelinsEndothelium, VascularEnzyme InhibitorsFree Radical ScavengersGlaucomaNitric Oxide DonorsNitric Oxide SynthaseNitric Oxide Synthase Type IIIOcular Physiological PhenomenaJournal Article

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Paul L Wood. 2003. Multifunctional drugs for endothelial dysfunction in diabetes and glaucoma.. https://pubmed.ncbi.nlm.nih.gov/12789607/

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A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup.

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