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Paired-like repression/activation in pituitary development.

Lorin E Olson·Jeremy S Dasen·Bong Gun Ju·Jessica Tollkuhn·Michael G Rosenfeld
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Abstract

Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.

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AnimalsBasic Helix-Loop-Helix ProteinsHomeodomain ProteinsHumansMutationOrganogenesisPituitary GlandTranscription Factor HES-1Journal ArticleReview

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Lorin E Olson, Jeremy S Dasen, Bong Gun Ju, Jessica Tollkuhn, Michael G Rosenfeld. 2003. Paired-like repression/activation in pituitary development.. https://doi.org/10.1210/rp.58.1.249

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