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The DNA polymerase alpha-primase complex: multiple functions and interactions.

Marco Muzi-Falconi·Michele Giannattasio·Marco Foiani·Paolo Plevani
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Abstract

DNA polymerase alpha (pol alpha) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol alpha is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase alpha-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.

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AnimalsCell CycleDNADNA DamageDNA Polymerase IDNA PrimaseDNA ReplicationEukaryotic CellsGene Expression RegulationMacromolecular SubstancesModels, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Marco Muzi-Falconi, Michele Giannattasio, Marco Foiani, Paolo Plevani. 2003-03-17. The DNA polymerase alpha-primase complex: multiple functions and interactions.. https://doi.org/10.1100/tsw.2003.05

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