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A CD40 bridge between innate and adaptive immunity.

Edward A Clark·Andrew Craxton
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Abstract

In this issue of Immunity, Brodeur et al. show that C4b binding protein (C4BP), a regulator component of the classical complement (C) pathway, can bind to CD40 receptors on B cells and activate them. This suggests a novel way by which CD40 may function to bridge innate and adaptive immune responses.

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AnimalsB-LymphocytesCD40 AntigensComplement Inactivator ProteinsGlycoproteinsHumansImmunity, InnateReceptors, Cell SurfaceJournal ArticleComment

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Edward A Clark, Andrew Craxton. 2003. A CD40 bridge between innate and adaptive immunity.. https://doi.org/10.1016/s1074-7613(03)00146-8

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