Update on estrogen signaling.

Zhang Weihua; Sandra Andersson; Guojun Cheng; Evan R Simpson; Margaret Warner; Jan-Ake Gustafsson

doi:10.1016/s0014-5793(03)00436-8

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Update on estrogen signaling.

Zhang Weihua·Sandra Andersson·Guojun Cheng·Evan R Simpson·Margaret Warner·Jan-Ake Gustafsson

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Abstract

Our understanding of estrogen signaling has undergone a true paradigm shift over recent years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor beta (ERbeta). In many contexts ERbeta appears to antagonize the actions of ERalpha (yin/yang relationship) although there also exist genes that are specifically regulated by one of the two receptors. Studies of ERbeta knockout mice have shown that ERbeta exerts important functions in the ovary, central nervous system, mammary gland, prostate gland, hematopoiesis, immune system, vessels and bone. The use of ERbeta-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERbeta.

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Animals Breast Neoplasms Estrogens Female Humans Ligands Male Mammary Glands, Animal Mice Mice, Knockout Prostate Receptors, Estrogen Signal Transduction Tissue Distribution Lecture Research Support, Non-U.S. Gov't

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Zhang Weihua, Sandra Andersson, Guojun Cheng, Evan R Simpson, Margaret Warner, Jan-Ake Gustafsson. 2003-07-03. Update on estrogen signaling.. https://doi.org/10.1016/s0014-5793(03)00436-8

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