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PubMed · 12836412

[Triggering cell mitosis in higher eukaryotes].

Marcel Dorée
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Abstract

Dramatic changes of cell organisation occur at onset of mitosis. Genetic analysis of fission yeast and physiological studies of vertebrate and invertebrate oocytes showed that activation of cyclin B-cdc2 kinase triggers mitosis. Nevertheless, upstream mechanisms responsible for this activation remain largely unknown in somatic cells of higher eukaryotes. This review discusses possible pathways and mechanisms involved in triggering onset of mitosis in such cells, including inhibitory checkpoint mechanisms that detect defects in structural organisation of the cell.

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AnimalsCDC2-CDC28 KinasesChromosomesCyclin BCyclin-Dependent KinasesDNA ReplicationEukaryotic CellsGene Expression Regulation, DevelopmentalHumansInvertebratesMitosisProtein KinasesVertebratesYeastsEnglish AbstractJournal ArticleReview

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Marcel Dorée. 2003. [Triggering cell mitosis in higher eukaryotes].. https://doi.org/10.1051/medsci%2F2003193299

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