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The TNF receptor 1: a split personality complex.

Bryan C Barnhart·Marcus E Peter
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Abstract

The tumor necrosis factor receptor 1 (TNFR1), a prototypic member of the death receptor family signals both cell survival and apoptosis. In this issue of Cell, report that apoptotic TNFR1 signaling proceeds via the sequential formation of two distinct complexes. Since the first complex can activate survival signals and influence the activity of the second complex, this mechanism provides a checkpoint to control the execution of apoptosis.

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Adaptor Proteins, Signal TransducingApoptosisCASP8 and FADD-Like Apoptosis Regulating ProteinCarrier ProteinsCaspase 8Caspase 9CaspasesCell SurvivalFas-Associated Death Domain ProteinHumansIntracellular Signaling Peptides and ProteinsModels, BiologicalNF-kappa BNuclear Pore Complex ProteinsProtein Processing, Post-TranslationalProteinsRNA-Binding ProteinsReceptors, Tumor Necrosis FactorSignal TransductionTNF Receptor-Associated Factor 1Transcriptional ActivationTumor Necrosis Factor-alphafas ReceptorJournal ArticleComment

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Bryan C Barnhart, Marcus E Peter. 2003-07-25. The TNF receptor 1: a split personality complex.. https://doi.org/10.1016/s0092-8674(03)00561-0

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